Risk Assessment and Anticoagulation for Primary Stroke Prevention in Atrial Fibrillation

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Risk assessment and anticoagulation for primary stroke prevention in atrial fibrillation.

BACKGROUND AND PURPOSE Risk assessment before anticoagulation is important for effective stroke prevention in atrial fibrillation (AF). METHODS A study was undertaken in patients with AF to investigate the contribution of clinical and echocardiography (ECHO) criteria to treatment decisions on anticoagulation. Patients were stratified by age and stroke risk; contraindications to anticoagulatio...

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Anticoagulation for stroke prevention in atrial fibrillation: is gender important?

The presence of atrial fibrillation (AF) confers a five-fold increased risk of stroke, a figure that may rise to as high as 17 times in the presence of structural heart disease, in particular mitral stenosis. It is estimated that 15% of all strokes may be directly attributable to AF, but of greater concern is that when patients with AF have a stroke, they have a much worse outcome. Being an inc...

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National assessment of warfarin anticoagulation therapy for stroke prevention in atrial fibrillation.

BACKGROUND Anticoagulation control with warfarin, as assessed by the international normalized ratio (INR), is challenging. Time in the therapeutic range has been inversely correlated with major hemorrhage, thrombosis, and mortality. Quest Diagnostics offers standardized INR laboratory testing services to approximately half of US physician practices. To inform national stroke prevention strategi...

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Cost-effectiveness of anticoagulation in nonrheumatic atrial fibrillation in the primary prevention of ischemic stroke.

BACKGROUND AND PURPOSE A number of clinical trials have shown the value of anticoagulating patients with nonrheumatic atrial fibrillation to prevent ischemic stroke. The purpose of this study was to assess the cost-effectiveness of anticoagulation in nonrheumatic atrial fibrillation with particular reference to the very elderly (aged >75 years) who have a higher incidence of bleeding events whi...

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Patient's values and preferences for stroke prevention in atrial fibrillation: balancing stroke and bleeding risk with oral anticoagulation.

2014; 111: 465-473. Note: The review process for this editorial was handled by Christian Weber, Editor in Chief. Clinical guidelines for the management of atrial fibrillation (AF) advocate individual stroke risk assessment with CHA2DS2-VASc to determine a patient’s suitability for oral anticoagulation (OAC), followed by formal appraisal of their bleeding risk associated with OAC, using the HAS-...

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ژورنال

عنوان ژورنال: Stroke

سال: 1999

ISSN: 0039-2499,1524-4628

DOI: 10.1161/01.str.30.6.1218